From I-70 – take I-70 east to the Grand exit, turn right onto Grand Boulevard and take south to Lindell Boulevard. Turn right onto Lindell and follow west to the Cathedral.
From I-44 – take I-44 east to the Kingshighway exit, turn left onto Kingshighway and follow to Lindell Boulevard. Turn right onto Lindell to the Cathedral.
From I-170 – take Forest Park Parkway east to Newstead Avenue. Turn left onto Newstead and take to the Cathedral.
Manchester – take Manchester Road east to Newstead Avenue and turn left onto Newstead, follow north to the Cathedral.
Olive – take Olive east to Skinker Boulevard. Turn right onto Skinker and follow to Lindell Boulevard. Turn left onto Lindell and follow to the Cathedral.
From Illinois on I-64/40 – take I-64/40 west to the Grand Ave./Forest Park Parkway exit. Go straight to stay on Forest Park Parkway to Newstead Avenue. Turn right on Newstead and follow to the Cathedral.